Isoxazolone based inhibitors of p38 MAP kinases

Stefan A Laufer; Simona Margutti

doi:10.1021/jm701343f

Isoxazolone based inhibitors of p38 MAP kinases

J Med Chem. 2008 Apr 24;51(8):2580-4. doi: 10.1021/jm701343f. Epub 2008 Mar 29.

Authors

Stefan A Laufer¹, Simona Margutti

Affiliation

¹ Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Eberhard Karls University of Tuebingen, Auf der Morgenstelle 8, 72076 Tuebingen, Germany. stefan.laufer@uni-tuebingen.de

PMID: 18373337
DOI: 10.1021/jm701343f

Abstract

SAR of N-alkylated isoxazolones as p38 MAP kinase inhibitors was realized. The data herein show the possibility of transferring the SAR study and evaluation from N-1-substituted imidazole to isoxazolones. Optimization of substituent was realized.

MeSH terms

Magnetic Resonance Spectroscopy
Oxazoles / pharmacology*
Protein Kinase Inhibitors / pharmacology*
Spectroscopy, Fourier Transform Infrared
p38 Mitogen-Activated Protein Kinases / antagonists & inhibitors*

Substances

Oxazoles
Protein Kinase Inhibitors
p38 Mitogen-Activated Protein Kinases